Toonpack 9298 Posted March 23, 2022 Share Posted March 23, 2022 31 minutes ago, Renton said: See, is that first sentence true? As I've said, I'm no virologist, I'm thinking here from first principles, but my understanding is omicron took over because it was more contagious and out-competed delta. This was because it was more effective at infecting the upper respiratory tract, but the flip side of this was less effective at infecting the lower respiratory tract, which causes more serious consequences like pneumonia. The virus can't do both (due to its molecular anatomy), its a matter of trade offs, which suggests to me the evolutionary pressure should be in favour of the virus being more effective at infecting the upper respiratory tract whilst sparing other organ systems. I think in general respiratory viruses which are unstable tend to mutate in a more benign direction, which is why there dozens of strains that cause common cold which whilst being unpleasant, are fairly harmless. Thoughts? Aye, plenty of articles about https://www.theguardian.com/world/2022/jan/11/will-covid-19-become-less-dangerous-as-it-evolves Link to comment Share on other sites More sharing options...
spongebob toonpants 3956 Posted March 23, 2022 Share Posted March 23, 2022 41 minutes ago, Renton said: See, is that first sentence true? As I've said, I'm no virologist, I'm thinking here from first principles, but my understanding is omicron took over because it was more contagious and out-competed delta. This was because it was more effective at infecting the upper respiratory tract, but the flip side of this was less effective at infecting the lower respiratory tract, which causes more serious consequences like pneumonia. The virus can't do both (due to its molecular anatomy), its a matter of trade offs, which suggests to me the evolutionary pressure should be in favour of the virus being more effective at infecting the upper respiratory tract whilst sparing other organ systems. I think in general respiratory viruses which are unstable tend to mutate in a more benign direction, which is why there dozens of strains that cause common cold which whilst being unpleasant, are fairly harmless. Thoughts? Sadly even the latest pandemic proves that not true. Alpha was worse than OG Coviid, and Delta was worse than that. Just need to keep our fingers crossed that we don't get a worse variant because there won't be any more mitigation and it will be carnage Link to comment Share on other sites More sharing options...
Renton 21393 Posted March 23, 2022 Share Posted March 23, 2022 25 minutes ago, Toonpack said: Aye, plenty of articles about https://www.theguardian.com/world/2022/jan/11/will-covid-19-become-less-dangerous-as-it-evolves Honestly though, that article doesn't really address the points I made about upper vs lower respiratory infection. I'm definitely saying its impossible we could get a more dealy variant, but I can't understand how a more deadly one (that targets the lower respiratory tract) could be more infectious? Also I'm yet to see data which shows alpha and delta were more severe than the original wild type. The presence of mass vaccinations and natural immunity confuses matters somewhat of course. Link to comment Share on other sites More sharing options...
Alex 34913 Posted March 23, 2022 Share Posted March 23, 2022 In the office today and about half the place seems to be coughing. There’s an expectation atm to come in 40% of the time (although loads of people clearly aren’t). But there’s also an understanding that you don’t need to come in if you’re at all symptomatic. So why the fuck would you? Idiots, man Link to comment Share on other sites More sharing options...
Tom 14011 Posted March 23, 2022 Share Posted March 23, 2022 Aye I popped in for a meeting and 2 out of the 4 people were coughing FFS Link to comment Share on other sites More sharing options...
Isegrim 9737 Posted March 23, 2022 Share Posted March 23, 2022 Numbers here are still very high but most restrictions will come to an end on Aptil 2nd. Weird. I am not sure how the antivaccers and other idiots will survive because they told us that the deep state wanted to keep restrictions forever to take control over us. Link to comment Share on other sites More sharing options...
Tom 14011 Posted March 23, 2022 Share Posted March 23, 2022 They’ll move on to Putin & the war. Link to comment Share on other sites More sharing options...
Toonpack 9298 Posted March 23, 2022 Share Posted March 23, 2022 7 minutes ago, Tom said: They’ll move on to Putin & the war. My local village idiot has already, it's a hoax as well btw. Link to comment Share on other sites More sharing options...
Rayvin 5186 Posted March 23, 2022 Share Posted March 23, 2022 17 minutes ago, Isegrim said: I am not sure how the antivaccers and other idiots will survive because they told us that the deep state wanted to keep restrictions forever to take control over us. This is a salient point indeed. If restrictions are being lifted, what was the point from an 'authoritarian, control oriented' POV? There clearly was none, which blows their entire fucking standpoint out of the water. Also I'm now seeing some of the anti-vax people I know coming down with COVID, and it's fully wiping them out. The attempts to put a brave face on it are painful. You were wrong, lads. That's it. You believed a conspiracy theory propagated by people who hate you, and they did you up good and proper. That's all there is to it. The scientific community, and experts, the people who spend their lives dedicated to protecting you from your idiocy and conspiracy theories, were right. See also Brexit, Trump, voting for the Tories, mental health and late stage capitalism. Link to comment Share on other sites More sharing options...
spongebob toonpants 3956 Posted March 23, 2022 Share Posted March 23, 2022 9 minutes ago, Rayvin said: This is a salient point indeed. If restrictions are being lifted, what was the point from an 'authoritarian, control oriented' POV? There clearly was none, which blows their entire fucking standpoint out of the water. Also I'm now seeing some of the anti-vax people I know coming down with COVID, and it's fully wiping them out. The attempts to put a brave face on it are painful. You were wrong, lads. That's it. You believed a conspiracy theory propagated by people who hate you, and they did you up good and proper. That's all there is to it. The scientific community, and experts, the people who spend their lives dedicated to protecting you from your idiocy and conspiracy theories, were right. See also Brexit, Trump, voting for the Tories, mental health and late stage capitalism. Facts don't mean anything to these idiots. They will just pivot to the next bullshit talking point 2 Link to comment Share on other sites More sharing options...
Ayatollah Hermione 13837 Posted March 23, 2022 Share Posted March 23, 2022 Starting to spread like wildfire again at our place. One lass is off and it sounds like it's kicking her all over atm. Seems like it's on her chest and she can barely breathe with it but, in reassuring news, none of the managers know the protocol so if it comes my way, I'm staying off and demanding full pay and claiming managerial ignorance/incompetence if I'm docked. Link to comment Share on other sites More sharing options...
MMXXVIII 1293 Posted March 23, 2022 Share Posted March 23, 2022 On 16/03/2022 at 02:49, RobinRobin said: Is that you LM? No. Link to comment Share on other sites More sharing options...
Andrew 4721 Posted March 23, 2022 Share Posted March 23, 2022 Looks like most restrictions are starting to be relaxed here over the next few weeks, vaccine passes and QR code scanning no longer mandatory, masks still required for now at least but might not be for long. Starting to get to the point where I know a few people here who have it, which I haven't up to now. Protestors and anti-vaxxers of course claiming the end of restrictions is because of them which is annoying but at least they'll fuck off and stop clogging up the city centre with protests and go back to...complaining about something else probably. Link to comment Share on other sites More sharing options...
Sonatine 11329 Posted March 24, 2022 Share Posted March 24, 2022 Tested postive this morning with absolutely no symptoms so far (and let's keep it that way), so it's a few days off work for me. Link to comment Share on other sites More sharing options...
trooper 940 Posted March 24, 2022 Share Posted March 24, 2022 Dad rang me yesterday he's 85 he tested positive a couple of days ago he's got a cough & chest infection. He's on antibiotics & steroids for the chest infection I'm ringing him this morning for an update. He's been looking after his partner she's had it for a week & he's obviously picked it up from her. They live in in Warrington, luckily we have family members there to drop any food & meds they need. They're both triple jabbed so hopefully that'll help them fight the bastard off. 6 Link to comment Share on other sites More sharing options...
Gemmill 44498 Posted March 24, 2022 Share Posted March 24, 2022 Hope all turns out well troops. I'm sure it will. 2 Link to comment Share on other sites More sharing options...
Monkeys Fist 42129 Posted March 24, 2022 Share Posted March 24, 2022 Fucks sake- Mrs Fist has tested positive, having no doubt picked it up from some mackem skank at work. I’m supposed to be meeting with a parole officer tomorrow re. my brother’s killer, and I’ll be perturbed if it gets cancelled. Perturbed, I tell you! Link to comment Share on other sites More sharing options...
The Fish 10779 Posted March 24, 2022 Share Posted March 24, 2022 Don't tell 'em. Infect the PO, hopefully they'll infect the murderer. Might mean you've got to snog the PO, but don't tell me you haven't thought about it. 3 Link to comment Share on other sites More sharing options...
Monkeys Fist 42129 Posted March 24, 2022 Share Posted March 24, 2022 Well, I have now. Link to comment Share on other sites More sharing options...
OTF 7280 Posted March 24, 2022 Share Posted March 24, 2022 6 minutes ago, The Fish said: Don't tell 'em. Infect the PO, hopefully they'll infect the murderer. Might mean you've got to snog the PO, but don't tell me you haven't thought about it. Plot twist: She's a woman. From Thailand. 1 Link to comment Share on other sites More sharing options...
Monkeys Fist 42129 Posted March 24, 2022 Share Posted March 24, 2022 7 minutes ago, OTF said: Plot twist: She's a woman. From Thailand. Called Peggy. 3 Link to comment Share on other sites More sharing options...
Renton 21393 Posted March 24, 2022 Share Posted March 24, 2022 Peggy the Pegger. MF's ears light up. Link to comment Share on other sites More sharing options...
trooper 940 Posted March 24, 2022 Share Posted March 24, 2022 Day just keeps getting better Miss T had to ring in sick this morning (sore throat feeling sick) just done 3 tests all came back positive. She's obviously picked it up from school were she teaches. She said a few of her kids were coughing yesterday they've obviously passed it on to her. Link to comment Share on other sites More sharing options...
Gemmill 44498 Posted March 24, 2022 Share Posted March 24, 2022 Aye my lass is on day 8. Same story, picked it up from kids in her class. Link to comment Share on other sites More sharing options...
trooper 940 Posted March 24, 2022 Share Posted March 24, 2022 The other 4 of us in the house have all tested negative. So its definitely come from the school Link to comment Share on other sites More sharing options...
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