Difference is that Isak's was down to having issues in both knees and then an awkward groin injury which he's young enough to recover from without issue. Wilson's is his age and a mountain of serious injuries down the years all starting to stack up.
I think we need to adapt a little to get the most out of him, as he's never going to be pressing defenders for 90 minutes, but if he gets a yard of space in the box it's almost always a goal. Definitely not finished, but we may need to try something a bit different until Isak is back to really get the best out of Wilson.
Two inside forwards cutting in all game pretty much takes him out of the equation half the time as they either shoot or play through balls he doesn't have the pace to get on to. As @The Fish has said, it works better with Murphy out right as it pulls a centre back out wide and then him and Trippier can fire balls in which Wilson has the space to bury.