Think a lot of it depends on how well you can handle them, and the after effects.
The come down for me, three or so days after a pill for example, just became too much. Logically I knew it was the drugs, but could I fuck see through it.
Got well into coke for a while, but man it's expensive...and it narf turns a lot of people into greedy fuckers (in terms of the drug and general chat on the night)
Pills every weekend when living in Manchester in the late 90's - agree with what others have said in terms of it being great like, but also changing your outlook for the better forever more. Just became a tad repetitive for me, heh.
Gave up the weed around a month ago, mainly because I cannit seem to get me hands on owt decent, to be honest.